Inflammatory monocytes promote perineural invasion via CCL2-mediated recruitment and cathepsin B expression

Perineural invasion (PNI) is an ominous event strongly linked to poor clinical outcome. Cells residing within peripheral nerves collaborate with cancer cells to enable PNI but the contributing conditions within the tumor microenvironment are not well understood. Here we show that CCR2-expressing inf...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Bakst, Richard L., Xiong, Huizhong, Chen, Chun-Hao, Deborde, Sylvie, Lyubchik, Anna, Zhou, Yi, He, Shizhi, McNamara, William, Lee, Sei-Young, Olson, Oakley C., Leiner, Ingrid M., Marcadis, Andrea R., Keith, James W., Al-Ahmadie, Hikmat A., Katabi, Nora, Gil, Ziv, Vakiani, Efsevia, Joyce, Johanna A., Pamer, Eric, Wong, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831809/
https://ncbi.nlm.nih.gov/pubmed/28951461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1612
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