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Antidiabetic disruptors of the glucokinase-glucokinase regulatory protein complex reorganize a coulombic interface
The glucokinase regulatory protein (GKRP) plays an essential role in glucose homeostasis by acting as a competitive inhibitor of glucokinase (GCK) and triggering its localization to the hepatocyte nucleus upon glucose deprivation. Metabolites such as fructose 6-phosphate and sorbitol 6-phosphate pro...
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| Veröffentlicht in: | Biochemistry |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5831357/ https://ncbi.nlm.nih.gov/pubmed/28516783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00377 |
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