Metformin improves ovarian follicle dynamics by reducing theca cell proliferation and CYP-17 expression in an androgenized rat model

BACKGROUND: Metformin influences insulin receptor signaling, which might interfere with the proliferation of ovarian follicular structures and steroidogenesis. We hypothesize that reductions in glucose and insulin levels might interfere with CYP-17 expression and histomorphological changes in an and...

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Detalhes bibliográficos
Publicado no:J Ovarian Res
Main Authors: Mahamed, Roberta Rassi, Maganhin, Carla Cristina, Sasso, Gisela Rodrigues Silva, de Jesus Simões, Manuel, Baracat, Maria Candida Pinheiro, Baracat, Edmund Chada, Soares-, José Maria
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831207/
https://ncbi.nlm.nih.gov/pubmed/29490689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13048-018-0392-1
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