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The Involvement of Granulosa Cells in the Regulation by Gonadotropins of Cyp17a1 in Theca Cells

Background/Aim: Theca cells produce androgen by 17α-hydroxylase-17,20-lyase encoded by Cyp17a1, and conversion of androgen to estrogen in granulosa cells is regulated by gonadotropins. Women with polycystic ovarian syndrome (PCOS) exhibit elevated levels of androgens due to high Cyp17a1 expression a...

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Pubblicato in:In Vivo
Autori principali: KAKUTA, HANAKO, IGUCHI, TAISEN, SATO, TOMOMI
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Institute of Anticancer Research 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365763/
https://ncbi.nlm.nih.gov/pubmed/30348693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21873/invivo.11391
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