Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination

The nitric oxide (NO)-cyclic GMP pathway contributes to human stem cell differentiation, but NO free radical production can also damage DNA, necessitating a robust DNA damage response (DDR) to ensure cell survival. How the DDR is affected by differentiation is unclear. Differentiation of stem cells,...

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Publicat a:Stem Cell Reports
Autors principals: Mujoo, Kalpana, Pandita, Raj K., Tiwari, Anjana, Charaka, Vijay, Chakraborty, Sharmistha, Singh, Dharmendra Kumar, Hambarde, Shashank, Hittelman, Walter N., Horikoshi, Nobuo, Hunt, Clayton R., Khanna, Kum Kum, Kots, Alexander Y., Butler, E. Brian, Murad, Ferid, Pandita, Tej K.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831054/
https://ncbi.nlm.nih.gov/pubmed/29103969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.10.002
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