Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression

Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab and Pembrolizumab) antibodies alone or in combination has shown remarkable efficacy in multiple cancer types, concomitant with immune-related a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Guo, Yanxia, Walsh, Alice M., Canavan, Mary, Wechalekar, Mihir D., Cole, Suzanne, Yin, Xuefeng, Scott, Brittney, Loza, Mathew, Orr, Carl, McGarry, Trudy, Bombardieri, Michele, Humby, Frances, Proudman, Susanna M., Pitzalis, Costantino, Smith, Malcolm D., Friedman, Joshua R., Anderson, Ian, Madakamutil, Loui, Veale, Douglas J., Fearon, Ursula, Nagpal, Sunil
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831027/
https://ncbi.nlm.nih.gov/pubmed/29489833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192704
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