Inhibition of IL‐6‐JAK/Stat3 signaling in castration‐resistant prostate cancer cells enhances the NK cell‐mediated cytotoxicity via alteration of PD‐L1/NKG2D ligand levels

To investigate whether IL‐6 signaling affects the susceptibility of castration‐resistant prostate cancer (CRPC) cells to cytotoxic action of natural killer (NK) cells, CRPC cell lines (having different IL‐6 levels) were developed by lentiviral transduction. While observing no secreted IL‐6 level in...

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Vydáno v:Mol Oncol
Hlavní autoři: Xu, LiJun, Chen, XiaoDong, Shen, MingJing, Yang, Dong‐Rong, Fang, Laifu, Weng, Guobin, Tsai, Ying, Keng, Peter C., Chen, Yuhchyau, Lee, Soo Ok
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830627/
https://ncbi.nlm.nih.gov/pubmed/28865178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12135
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