Inhibition of IL‐6‐JAK/Stat3 signaling in castration‐resistant prostate cancer cells enhances the NK cell‐mediated cytotoxicity via alteration of PD‐L1/NKG2D ligand levels

To investigate whether IL‐6 signaling affects the susceptibility of castration‐resistant prostate cancer (CRPC) cells to cytotoxic action of natural killer (NK) cells, CRPC cell lines (having different IL‐6 levels) were developed by lentiviral transduction. While observing no secreted IL‐6 level in...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Xu, LiJun, Chen, XiaoDong, Shen, MingJing, Yang, Dong‐Rong, Fang, Laifu, Weng, Guobin, Tsai, Ying, Keng, Peter C., Chen, Yuhchyau, Lee, Soo Ok
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830627/
https://ncbi.nlm.nih.gov/pubmed/28865178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12135
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