Targeting glioma stem‐like cell survival and chemoresistance through inhibition of lysine‐specific histone demethylase KDM2B

Glioblastoma (GBM) ranks among the most lethal cancers, with current therapies offering only palliation. Inter‐ and intrapatient heterogeneity is a hallmark of GBM, with epigenetically distinct cancer stem‐like cells (CSCs) at the apex. Targeting GSCs remains a challenging task because of their uniq...

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Dettagli Bibliografici
Pubblicato in:Mol Oncol
Autori principali: Staberg, Mikkel, Rasmussen, Rikke Darling, Michaelsen, Signe Regner, Pedersen, Henriette, Jensen, Kamilla Ellermann, Villingshøj, Mette, Skjoth‐Rasmussen, Jane, Brennum, Jannick, Vitting‐Seerup, Kristoffer, Poulsen, Hans Skovgaard, Hamerlik, Petra
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830623/
https://ncbi.nlm.nih.gov/pubmed/29360266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12174
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