Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

Resetting tumor-associated macrophages (TAMs) is a promising strategy to ameliorate the immunosuppressive tumor microenvironment and improve innate and adaptive antitumor immunity. Here we show that chloroquine (CQ), a proven anti-malarial drug, can function as an antitumor immune modulator that swi...

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Pubblicato in:Nat Commun
Autori principali: Chen, Degao, Xie, Jing, Fiskesund, Roland, Dong, Wenqian, Liang, Xiaoyu, Lv, Jiadi, Jin, Xun, Liu, Jinyan, Mo, Siqi, Zhang, Tianzhen, Cheng, Feiran, Zhou, Yabo, Zhang, Huafeng, Tang, Ke, Ma, Jingwei, Liu, Yuying, Huang, Bo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830447/
https://ncbi.nlm.nih.gov/pubmed/29491374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03225-9
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