FcαRI co-stimulation converts human intestinal CD103(+) dendritic cells into pro-inflammatory cells through glycolytic reprogramming

CD103(+) dendritic cells (DC) are crucial for regulation of intestinal tolerance in humans. However, upon infection of the lamina propria this tolerogenic response is converted to an inflammatory response. Here we show that immunoglobulin A (IgA) immune complexes (IgA-IC), which are present after ba...

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Publicado no:Nat Commun
Main Authors: Hansen, Ivo S., Krabbendam, Lisette, Bernink, Jochem H., Loayza-Puch, Fabricio, Hoepel, Willianne, van Burgsteden, Johan A., Kuijper, Elsa C., Buskens, Christianne J., Bemelman, Willem A., Zaat, Sebastiaan A. J., Agami, Reuven, Vidarsson, Gestur, van den Brink, Gijs R., de Jong, Esther C., Wildenberg, Manon E., Baeten, Dominique L. P., Everts, Bart, den Dunnen, Jeroen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830413/
https://ncbi.nlm.nih.gov/pubmed/29491406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03318-5
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