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Synthesis of N-alkoxy-substituted 2H-benzimidazoles

Treatment of 2-nitro-N-(2-methyl-1-propen-1-yl)benzenamines with potassium tert-butoxide in tert-butanol followed by the addition of an electrophile affords N-alkoxy-2H-benzimidazoles. Electrophiles including methyl iodide, allylic bromides, propargylic bromides, benzyl bromide, and acetyl chloride...

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Bibliographic Details
Published in:Tetrahedron Lett
Main Authors: Ansari, Nurul H., Söderberg, Björn C. G.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830180/
https://ncbi.nlm.nih.gov/pubmed/29503480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2017.11.007
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