The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes

eIF2B is a dedicated guanine nucleotide exchange factor for eIF2, the GTPase that is essential to initiate mRNA translation. The integrated stress response (ISR) signaling pathway inhibits eIF2B activity, attenuates global protein synthesis and upregulates a set of stress-response proteins. Partial...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Wong, Yao Liang, LeBon, Lauren, Edalji, Rohinton, Lim, Hock Ben, Sun, Chaohong, Sidrauski, Carmela
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2018
Ämnen:
Biochemistry and Chemical Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829914/
https://ncbi.nlm.nih.gov/pubmed/29489452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32733
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