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The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes
eIF2B is a dedicated guanine nucleotide exchange factor for eIF2, the GTPase that is essential to initiate mRNA translation. The integrated stress response (ISR) signaling pathway inhibits eIF2B activity, attenuates global protein synthesis and upregulates a set of stress-response proteins. Partial...
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| Publicado en: | eLife |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5829914/ https://ncbi.nlm.nih.gov/pubmed/29489452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32733 |
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