Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D(3)-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in Humans

Metabolism of 25-hydroxyvitamin D(3) (25OHD(3)) plays a central role in regulating the biologic effects of vitamin D in the body. Although cytochrome P450–dependent hydroxylation of 25OHD(3) has been extensively investigated, limited information is available on the conjugation of 25OHD(3). In this s...

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Udgivet i:Drug Metab Dispos
Main Authors: Wong, Timothy, Wang, Zhican, Chapron, Brian D., Suzuki, Mizuki, Claw, Katrina G., Gao, Chunying, Foti, Robert S., Prasad, Bhagwat, Chapron, Alenka, Calamia, Justina, Chaudhry, Amarjit, Schuetz, Erin G., Horst, Ronald L., Mao, Qingcheng, de Boer, Ian H., Thornton, Timothy A., Thummel, Kenneth E.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829543/
https://ncbi.nlm.nih.gov/pubmed/29343609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.078428
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