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The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of β-catenin, a GSK3 substrate, in human glioblastoma cells

Lithium salt is a classic glycogen synthase kinase 3 (GSK3) inhibitor. Beryllium is a structurally related inhibitor that is more potent but relatively uncharacterized. This study examined the effects of these inhibitors on the phosphorylation of endogenous GSK3 substrates. In NIH-3T3 cells, both sa...

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Dades bibliogràfiques
Publicat a:Biol Open
Autors principals: Abdul, Ata ur Rahman Mohammed, De Silva, Bhagya, Gary, Ronald K.
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829510/
https://ncbi.nlm.nih.gov/pubmed/29212798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.030874
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