Individualized treatment strategies for hyperuricemia informed by a semi‐mechanistic exposure‐response model of uric acid dynamics

To provide insight into pharmacological treatment of hyperuricemia we developed a semi‐mechanistic, dynamical model of uric acid (UA) disposition in human. Our model represents the hyperuricemic state in terms of production of UA (rate, PUA), its renal filtration (glomerular filtration rate, GFR) an...

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Detaylı Bibliyografya
Yayımlandı:Physiol Rep
Asıl Yazarlar: Aksenov, Sergey, Peck, Carl C., Eriksson, Ulf G., Stanski, Donald R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2018
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828935/
https://ncbi.nlm.nih.gov/pubmed/29488355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13614
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