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Individualized treatment strategies for hyperuricemia informed by a semi‐mechanistic exposure‐response model of uric acid dynamics

To provide insight into pharmacological treatment of hyperuricemia we developed a semi‐mechanistic, dynamical model of uric acid (UA) disposition in human. Our model represents the hyperuricemic state in terms of production of UA (rate, PUA), its renal filtration (glomerular filtration rate, GFR) an...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Aksenov, Sergey, Peck, Carl C., Eriksson, Ulf G., Stanski, Donald R.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828935/
https://ncbi.nlm.nih.gov/pubmed/29488355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13614
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