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Novel C-Terminal Hsp90 Inhibitor for Head and Neck Squamous Cell Cancer (HNSCC) with in vivo Efficacy and Improved Toxicity Profiles Compared with Standard Agents

BACKGROUND: Current therapies for HNSCC, especially platinum agents, are limited by their toxicities and drug resistance. This study evaluates a novel C-terminal Hsp90 inhibitor (CT-Hsp90-I) for efficacy and toxicity in vitro and in vivo in an orthotopic HNSCC model. Our hypothesis is that C-termina...

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Detalles Bibliográficos
Publicado en:Ann Surg Oncol
Main Authors: Cohen, Stephanie M., Mukerji, Ridhwi, Samadi, Abbas K., Zhao, Huiping, Blagg, Brian S. J., Cohen, Mark S.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828498/
https://ncbi.nlm.nih.gov/pubmed/21837531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-011-1971-1
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