The non-neuronal cyclin-dependent kinase 5 is a fibrotic mediator potentially implicated in systemic sclerosis and a novel therapeutic target

The mechanisms underlying persistent fibroblast activation and myofibroblast phenoconversion in underlying multi-organ fibrosis in systemic sclerosis (SSc) remain incompletely understood, hindering effective therapies to slow or reverse the process. Cyclin-dependent kinase 5 (CDK5) is a pleiotropic...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wei, Jun, Marangoni, Roberta G., Fang, Feng, Wang, Wenxia, Huang, Jingang, Distler, Joerg H.W., Varga, John
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828185/
https://ncbi.nlm.nih.gov/pubmed/29535807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23516
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