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Multidimensional control of Cas9 by evolved RNA polymerase-based biosensors
Systems to control Cas9 with spatial and temporal precision offer opportunities to decrease side effects, protect sensitive tissues, and create gene therapies that are only activated at defined times and places. Here, we present the design of new Cas9 controllers based on RNA polymerase (RNAP)-based...
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| Veröffentlicht in: | ACS Chem Biol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5828011/ https://ncbi.nlm.nih.gov/pubmed/28809467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00532 |
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