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The efficacy of Ranolazine on E1784K is altered by temperature and calcium
E1784K is the most common mixed syndrome SCN5a mutation underpinning both Brugada syndrome type 1 (BrS1) and Long-QT syndrome type 3 (LQT3). The charge reversal mutant enhances the late sodium current (I(Na)) passed by the cardiac voltage-gated sodium channel (Na(V)1.5), delaying cardiac repolarizat...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5827758/ https://ncbi.nlm.nih.gov/pubmed/29483621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22033-1 |
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