Oxidation of the FAD cofactor to the 8-formyl-derivative in human electron-transferring flavoprotein

The heterodimeric human (h) electron-transferring flavoprotein (ETF) transfers electrons from at least 13 different flavin dehydrogenases to the mitochondrial respiratory chain through a non-covalently bound FAD cofactor. Here, we describe the discovery of an irreversible and pH-dependent oxidation...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Augustin, Peter, Toplak, Marina, Fuchs, Katharina, Gerstmann, Eva Christine, Prassl, Ruth, Winkler, Andreas, Macheroux, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827430/
https://ncbi.nlm.nih.gov/pubmed/29301933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000846
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