The Host Factor AUF1 p45 Supports Flavivirus Propagation by Triggering the RNA Switch Required for Viral Genome Cyclization

In previous studies, we showed that the cellular RNA-binding protein AUF1 supports the replication process of the flavivirus West Nile virus. Here we demonstrate that the protein also enables effective proliferation of dengue virus and Zika virus, indicating that AUF1 is a general flavivirus host fa...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Friedrich, Susann, Engelmann, Susanne, Schmidt, Tobias, Szczepankiewicz, Grit, Bergs, Sandra, Liebert, Uwe G., Kümmerer, Beate M., Golbik, Ralph P., Behrens, Sven-Erik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827407/
https://ncbi.nlm.nih.gov/pubmed/29263261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01647-17
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