Tacrolimus Reverses UVB Irradiation-Induced Epidermal Langerhans Cell Reduction by Inhibiting TNF-α Secretion in Keratinocytes via Regulation of NF-κB/p65

Background: Topical calcineurin inhibitors including tacrolimus and pimecrolimus are used in the treatment of many inflammatory skin diseases mainly via blocking T-cell proliferation. Our previous studies found that pimecrolimus 1% cream could reverse high-dose ultraviolet B (UVB) irradiation-induce...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Xu, JiaLi, Feng, YaDong, Song, GuoXin, Gong, QiXing, Yin, Li, Hu, YingYing, Luo, Dan, Yin, ZhiQiang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827091/
https://ncbi.nlm.nih.gov/pubmed/29520229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00067
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