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Cyclophilin J PPIase Inhibitors Derived from 2,3-Quinoxaline-6 Amine Exhibit Antitumor Activity

Cyclophilin J (CyPJ), also called peptidylprolyl isomerase like 3, has been identified as a novel member of the cyclophilin family. Our previous research has resolved the three-dimensional structure of CyPJ and demonstrated the peptidylprolyl cis–trans isomerase (PPIase) activity of CyPJ, which can...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Zhao, Xuemei, Xia, Chengcai, Wang, Xiaodan, Wang, Hao, Xin, Ming, Yu, Long, Liang, Yulong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826973/
https://ncbi.nlm.nih.gov/pubmed/29520233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00126
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