Novel cyclophilin D inhibitors derived from quinoxaline exhibit highly inhibitory activity against rat mitochondrial swelling and Ca(2+) uptake/release

AIM: To investigate methods for identifying specific cyclophilin D (CypD) inhibitors derived from quinoxaline, thus developing possible lead compounds to inhibit mitochondrial permeability transition (MPT) pore opening. METHODS: Kinetic analysis of the CypD/inhibitor interaction was quantitatively p...

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Vydáno v:Acta Pharmacol Sin
Hlavní autoři: Guo, Hong-xia, Wang, Feng, Yu, Kun-qian, Chen, Jing, Bai, Dong-lu, Chen, Kai-xian, Shen, Xu, Jiang, Hua-liang
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2005
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7091716/
https://ncbi.nlm.nih.gov/pubmed/16174436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1745-7254.2005.00189.x
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