NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus

Diurnal oscillation of intracellular redox potential is known to couple metabolism with the circadian clock, yet the responsible mechanisms are not well understood. We show here that chemical activation of NRF2 modifies circadian gene expression and rhythmicity, with phenotypes similar to genetic NR...

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Vydáno v:eLife
Hlavní autoři: Wible, Ryan S, Ramanathan, Chidambaram, Sutter, Carrie Hayes, Olesen, Kristin M, Kensler, Thomas W, Liu, Andrew C, Sutter, Thomas R
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2018
Témata:
Biochemistry and Chemical Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826263/
https://ncbi.nlm.nih.gov/pubmed/29481323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31656
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