Population Pharmacokinetics of Polymyxin B in Acutely Ill Adult Patients

Polymyxin B (PB) has reemerged as a common treatment against multidrug-resistant Gram-negative pathogens. However, nephrotoxicity remains a significant dose-limiting side effect, and contemporary pharmacokinetic (PK) data are limited. This study sought to evaluate PB exposure differences in various...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Miglis, Cristina, Rhodes, Nathaniel J., Avedissian, Sean N., Kubin, Christine J., Yin, Michael T., Nelson, Brian C., Pai, Manjunath P., Scheetz, Marc H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826159/
https://ncbi.nlm.nih.gov/pubmed/29311071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01475-17
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