Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis

Isoniazid and rifampin are essential components of first-line antituberculosis (anti-TB) therapy. Understanding the relationship between genetic factors and the pharmacokinetics of these drugs could be useful in optimizing treatment outcomes, but this is understudied in children. We investigated the...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Dompreh, Albert, Tang, Xiaoli, Zhou, Jianlin, Yang, Hongmei, Topletz, Ariel, Adu Ahwireng, Eugene, Antwi, Sampson, Enimil, Antony, Langaee, Taimour, Peloquin, Charles A., Court, Michael H., Kwara, Awewura
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826147/
https://ncbi.nlm.nih.gov/pubmed/29263072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02099-17
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