Depot Subcutaneous Injection with Chalcone CH8-Loaded Poly(Lactic-Co-Glycolic Acid) Microspheres as a Single-Dose Treatment of Cutaneous Leishmaniasis

Conventional chemotherapy of cutaneous leishmaniasis (CL) is based on multiple parenteral or intralesional injections with systemically toxic drugs. Aiming at a single-dose localized therapy, biodegradable poly(lactic-co-glycolic acid) (PLGA) microparticles loaded with 7.8% of an antileishmanial nit...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Sousa-Batista, Ariane de Jesus, Pacienza-Lima, Wallace, Arruda-Costa, Natalia, Falcão, Camila Alves Bandeira, Ré, Maria Ines, Rossi-Bergmann, Bartira
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826136/
https://ncbi.nlm.nih.gov/pubmed/29263064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01822-17
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