Successive Emergence of Ceftazidime-Avibactam Resistance through Distinct Genomic Adaptations in bla(KPC-2)-Harboring Klebsiella pneumoniae Sequence Type 307 Isolates

Ceftazidime-avibactam (CAZ-AVI) is a promising novel treatment for infections caused by carbapenem-resistant Enterobacteriaceae (CRE). Despite improved treatment outcomes compared to those achieved with aminoglycoside- and colistin-based regimens, the rapid evolution of CAZ-AVI resistance during tre...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Giddins, Marla J., Macesic, Nenad, Annavajhala, Medini K., Stump, Stephania, Khan, Sabrina, McConville, Thomas H., Mehta, Monica, Gomez-Simmonds, Angela, Uhlemann, Anne-Catrin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Epidemiology and Surveillance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826117/
https://ncbi.nlm.nih.gov/pubmed/29263067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02101-17
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