Replication Rapidly Recovers and Continues in the Presence of Hydroxyurea in Escherichia coli

In both prokaryotes and eukaryotes, hydroxyurea is suggested to inhibit DNA replication by inactivating ribonucleotide reductase and depleting deoxyribonucleoside triphosphate pools. In this study, we show that the inhibition of replication in Escherichia coli is transient even at concentrations of...

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Библиографические подробности
Опубликовано в: :J Bacteriol
Главные авторы: Nazaretyan, Samvel A., Savic, Neda, Sadek, Michael, Hackert, Brandy J., Courcelle, Justin, Courcelle, Charmain T.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2018
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826035/
https://ncbi.nlm.nih.gov/pubmed/29263100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00713-17
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