Replication Rapidly Recovers and Continues in the Presence of Hydroxyurea in Escherichia coli

In both prokaryotes and eukaryotes, hydroxyurea is suggested to inhibit DNA replication by inactivating ribonucleotide reductase and depleting deoxyribonucleoside triphosphate pools. In this study, we show that the inhibition of replication in Escherichia coli is transient even at concentrations of...

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Bibliographic Details
Published in:J Bacteriol
Main Authors: Nazaretyan, Samvel A., Savic, Neda, Sadek, Michael, Hackert, Brandy J., Courcelle, Justin, Courcelle, Charmain T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826035/
https://ncbi.nlm.nih.gov/pubmed/29263100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00713-17
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