CD4+ T Cell Help Is Mandatory for Naive and Memory Donor-Specific Antibody Responses: Impact of Therapeutic Immunosuppression

Antibody-mediated rejection is currently the leading cause of transplant failure. Prevailing dogma predicts that B cells differentiate into anti-donor-specific antibody (DSA)-producing plasma cells only with the help of CD4+ T cells. Yet, previous studies have shown that dependence on helper T cells...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Chen, Chien-Chia, Koenig, Alice, Saison, Carole, Dahdal, Suzan, Rigault, Guillaume, Barba, Thomas, Taillardet, Morgan, Chartoire, Dimitri, Ovize, Michel, Morelon, Emmanuel, Defrance, Thierry, Thaunat, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825980/
https://ncbi.nlm.nih.gov/pubmed/29515582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00275
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