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Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types
Quantitative mismatches between human physiology and experimental models can be problematic for the development of effective therapeutics. When the effects of drugs on human adult cardiac electrophysiology are of interest, phenotypic differences with animal cells, and more recently stem cell-derived...
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| Publicado no: | NPJ Syst Biol Appl |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5825396/ https://ncbi.nlm.nih.gov/pubmed/29507757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41540-018-0047-2 |
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