TGF-β1 Alters Esophageal Epithelial Barrier Function by Attenuation of Claudin-7 in Eosinophilic Esophagitis

Barrier dysfunction has been implicated in the pathophysiology of eosinophilic esophagitis (EoE). TGF-β1, a potent pleiotropic molecule, is increased in EoE, however, no study has evaluated its influence on esophageal epithelial barrier. We hypothesized that TGF-β1 regulates barrier dysfunction in E...

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Vydáno v:Mucosal Immunol
Hlavní autoři: Nguyen, Nathalie, Fernando, Shahan D., Biette, Kathryn A., Hammer, Juliet A., Capocelli, Kelley E., Kitzenberg, David A., Glover, Louise E., Colgan, Sean P., Furuta, Glenn T., Masterson, Joanne C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825237/
https://ncbi.nlm.nih.gov/pubmed/28832026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2017.72
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