Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion

Excess mineralocorticoid receptor (MR) activation promotes target organ dysfunction, vascular injury and fibrosis. MR antagonists like eplerenone are used for treating heart failure, but their use is limited due to the compound class-inherent hyperkalemia risk. Here we present evidence that AZD9977,...

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Pubblicato in:PLoS One
Autori principali: Bamberg, Krister, Johansson, Ulrika, Edman, Karl, William-Olsson, Lena, Myhre, Susanna, Gunnarsson, Anders, Geschwindner, Stefan, Aagaard, Anna, Björnson Granqvist, Anna, Jaisser, Frédéric, Huang, Yufeng, Granberg, Kenneth L., Jansson-Löfmark, Rasmus, Hartleib-Geschwindner, Judith
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825103/
https://ncbi.nlm.nih.gov/pubmed/29474466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193380
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