Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion

Excess mineralocorticoid receptor (MR) activation promotes target organ dysfunction, vascular injury and fibrosis. MR antagonists like eplerenone are used for treating heart failure, but their use is limited due to the compound class-inherent hyperkalemia risk. Here we present evidence that AZD9977,...

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Udgivet i:PLoS One
Main Authors: Bamberg, Krister, Johansson, Ulrika, Edman, Karl, William-Olsson, Lena, Myhre, Susanna, Gunnarsson, Anders, Geschwindner, Stefan, Aagaard, Anna, Björnson Granqvist, Anna, Jaisser, Frédéric, Huang, Yufeng, Granberg, Kenneth L., Jansson-Löfmark, Rasmus, Hartleib-Geschwindner, Judith
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825103/
https://ncbi.nlm.nih.gov/pubmed/29474466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193380
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