N‐ethyl‐N‐nitrosourea–Induced Adaptor Protein 2 Sigma Subunit 1 (Ap2s1) Mutations Establish Ap2s1 Loss‐of‐Function Mice

The adaptor protein‐2 sigma subunit (AP2σ), encoded by AP2S1, forms a heterotetrameric complex, with AP2α, AP2β, and AP2μ subunits, that is pivotal for clathrin‐mediated endocytosis, and AP2σ loss‐of‐function mutations impair internalization of the calcium‐sensing receptor (CaSR), a G‐protein–couple...

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Detalhes bibliográficos
Publicado no:JBMR Plus
Main Authors: Gorvin, Caroline M, Rogers, Angela, Stewart, Michelle, Paudyal, Anju, Hough, Tertius A, Teboul, Lydia, Wells, Sara, Brown, Steve DM, Cox, Roger D, Thakker, Rajesh V
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824975/
https://ncbi.nlm.nih.gov/pubmed/29479578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm4.10001
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