Dual strategies for Argonaute2 mediated biogenesis of erythroid miRNAs underlie conserved requirements for slicing in mammals

While Slicer activity of Argonaute is central to RNAi, conserved roles of Slicing in endogenous regulatory biology are less clear, especially in mammals. Biogenesis of erythroid Dicer-independent mir-451 involves Ago2 catalysis, but mir-451-KO mice do not phenocopy Ago2 catalytic-dead (Ago2-CD) mice...

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Udgivet i:Mol Cell
Main Authors: Jee, David, Yang, Jr-Shiuan, Park, Sun-Mi, Farmer, D’Juan, Wen, Jiayu, Chou, Timothy, Chow, Arthur, McManus, Michael T., Kharas, Michael G., Lai, Eric C.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824974/
https://ncbi.nlm.nih.gov/pubmed/29351846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.12.027
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