Dual strategies for Argonaute2 mediated biogenesis of erythroid miRNAs underlie conserved requirements for slicing in mammals

While Slicer activity of Argonaute is central to RNAi, conserved roles of Slicing in endogenous regulatory biology are less clear, especially in mammals. Biogenesis of erythroid Dicer-independent mir-451 involves Ago2 catalysis, but mir-451-KO mice do not phenocopy Ago2 catalytic-dead (Ago2-CD) mice...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell
Asıl Yazarlar: Jee, David, Yang, Jr-Shiuan, Park, Sun-Mi, Farmer, D’Juan, Wen, Jiayu, Chou, Timothy, Chow, Arthur, McManus, Michael T., Kharas, Michael G., Lai, Eric C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824974/
https://ncbi.nlm.nih.gov/pubmed/29351846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.12.027
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