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Phospholipase D functional ablation has a protective effect in an Alzheimer’s disease Caenorhabditis elegans model
Phospholipase D (PLD) is a key player in the modulation of multiple aspects of cell physiology and has been proposed as a therapeutic target for Alzheimer’s disease (AD). Here, we characterize a PLD mutant, pld-1, using the Caenorhabditis elegans animal model. We show that pld-1 animals present decr...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5824944/ https://ncbi.nlm.nih.gov/pubmed/29476137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21918-5 |
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