Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity

The compensatory proliferation of insulin-producing β cells is critical to maintaining glucose homeostasis at the early stage of type 2 diabetes. Failure of β cells to proliferate results in hyperglycemia and insulin dependence in patients. To understand the effect of the interplay between β cell co...

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Udgivet i:J Clin Invest
Main Authors: Ye, Risheng, Gordillo, Ruth, Shao, Mengle, Onodera, Toshiharu, Chen, Zhe, Chen, Shiuhwei, Lin, Xiaoli, SoRelle, Jeffrey A., Li, Xiaohong, Tang, Miao, Keller, Mark P., Kuliawat, Regina, Attie, Alan D., Gupta, Rana K., Holland, William L., Beutler, Bruce, Herz, Joachim, Scherer, Philipp E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824868/
https://ncbi.nlm.nih.gov/pubmed/29457786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97702
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