HIV latency is reversed by ACSS2-driven histone crotonylation

Eradication of HIV-1 (HIV) is hindered by stable viral reservoirs. Viral latency is epigenetically regulated. While the effects of histone acetylation and methylation at the HIV long-terminal repeat (LTR) have been described, our knowledge of the proviral epigenetic landscape is incomplete. We repor...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Jiang, Guochun, Nguyen, Don, Archin, Nancie M., Yukl, Steven A., Méndez-Lagares, Gema, Tang, Yuyang, Elsheikh, Maher M., Thompson, George R., Hartigan-O’Connor, Dennis J., Margolis, David M., Wong, Joseph K., Dandekar, Satya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824862/
https://ncbi.nlm.nih.gov/pubmed/29457784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98071
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