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Leveraging Population‐Based Clinical Quantitative Phenotyping for Drug Repositioning

Computational drug repositioning methods can scalably nominate approved drugs for new diseases, with reduced risk of unforeseen side effects. The majority of methods eschew individual‐level phenotypes despite the promise of biomarker‐driven repositioning. In this study, we propose a framework for di...

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Bibliographische Detailangaben
Veröffentlicht in:CPT Pharmacometrics Syst Pharmacol
Hauptverfasser: Brown, Adam S., Rasooly, Danielle, Patel, Chirag J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824113/
https://ncbi.nlm.nih.gov/pubmed/28941007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12258
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