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New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status

Calpain-2 belongs to a family of pleiotropic Cys-proteases with modulatory rather than degradative functions. Calpain (CAPN) overexpression has been controversially correlated with poor prognosis in several cancer types, including colorectal carcinoma (CRC). However, the mechanisms of substrate-reco...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Telechea-Fernández, Marcelino, Rodríguez-Fernández, Lucia, García, Concha, Zaragozá, Rosa, Viña, Juan, Cervantes, Andrés, García-Trevijano, Elena R.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823616/
https://ncbi.nlm.nih.gov/pubmed/29507677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23888
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