EGF-Induced Acetylation of Heterogeneous Nuclear Ribonucleoproteins Is Dependent on KRAS Mutational Status in Colorectal Cancer Cells

KRAS mutational status is considered a negative predictive marker of the response to anti-EGFR therapies in colorectal cancer (CRC) patients. However, conflicting data exist regarding the variable response to EGFR-targeted therapy. The effects of oncogenic KRAS on downstream targets were studied in...

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Bibliographic Details
Published in:PLoS One
Main Authors: Roda, Desamparados, Castillo, Josefa, Telechea-Fernández, Marcelino, Gil, Anabel, López-Rodas, Gerardo, Franco, Luís, González-Rodríguez, Patricia, Roselló, Susana, Pérez-Fidalgo, J. Alejandro, García-Trevijano, Elena R., Cervantes, Andrés, Zaragozá, Rosa
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482484/
https://ncbi.nlm.nih.gov/pubmed/26110767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130543
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