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Clearance of mutant huntingtin
Mutant huntingtin (htt) carries an expanded polyglutamine (polyQ) repeat (>36 glutamines) in its N-terminal region, which leads htt to become misfolded and kill neuronal cells in Huntington disease (HD). The cytotoxicity of N-terminal mutant htt fragments is evident by severe neurological phenoty...
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| Publicado no: | Autophagy |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5822432/ https://ncbi.nlm.nih.gov/pubmed/20519964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.6.5.12336 |
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