Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression

Tumors contain hostile inflammatory signals generated by aberrant proliferation, necrosis, and hypoxia. These signals are sensed and acted upon acutely by the Toll-like receptors (TLRs) to halt proliferation and activate an immune response. Despite the presence of TLR ligands within the microenviron...

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Udgivet i:Cell Stem Cell
Main Authors: Alvarado, Alvaro G., Thiagarajan, Praveena S., Mulkearns-Hubert, Erin E., Silver, Daniel J., Hale, James S., Alban, Tyler J., Turaga, Soumya M., Jarrar, Awad, Reizes, Ofer, Longworth, Michelle S., Vogelbaum, Michael A., Lathia, Justin D.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5822422/
https://ncbi.nlm.nih.gov/pubmed/28089910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.12.001
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