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KEAP1 editing using CRISPR/Cas9 for therapeutic NRF2 activation in primary human T lymphocytes
Oxidant stress modifies T lymphocyte activation and function. Previous work demonstrated that murine T cell specific Keap1 deletion enhances antioxidant capacity and protects from experimental acute kidney injury. Here, we used CRISPR technology to develop clinically translatable human T cell-specif...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5821541/ https://ncbi.nlm.nih.gov/pubmed/29352001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700812 |
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